Duplex Sequencing studies provide the Mutation Frequency (MF) data you need for mutagenicity testing and BMD modeling without having to wait for a TGR study.
TwinStrand now offers mutagenicity studies for nitrosamine impurities both in-house and through select service providers.
Mammalian Cell Gene Mutation
Transgenic Rodent (TGR) Assay
DuplexSeqTM Mutagenesis Assays
|Compatible with wild-type rodents|
|Compatible with all standard tissue types|
|Compatible with in vitro model systems|
|Can identify the specific mutations induced|
|Provides information about mutagenic mechanism|
TwinStrand’s DuplexSeqTM Mutagenesis Assays use error-corrected NGS (ecNGS) technology to characterize DNA mutations and calculate mutational frequencies.
Detailed product information can be found in our data sheet.
DuplexSeqTM Mutagenesis Assays include both the sample preparation kit and software that automatically analyzes your data and generates an easy-to-read report. This simple system is easily added to any genetic toxicology program—without the need for bioinformatics expertise.
|Kit Type||Product Name||Number of Reactions||Product Number|
|Human||TwinStrand Duplex Sequencing® Mutagenesis Panel (Human-50), v1.0||24||06-1005-02|
|Mouse||TwinStrand Duplex Sequencing® Mutagenesis Panel (Mouse-50), v1.0||24||06-1006-02|
|Rat||TwinStrand Duplex Sequencing® Mutagenesis Panel (Rat-50), v1.0||24||06-1007-02|
We’ve published with our collaborators a significant amount of data in prestigious, peer-reviewed journals that demonstrate the benefits of Duplex Sequencing in genetic toxicology.